Select Publications

    Ahmed, A. U., B. Thaci, A. L. Tobias, B. Auffinger, L. Zhang, Y. Cheng, C. K. Kim, et al. "A Preclinical Evaluation of Neural Stem Cell-Based Cell Carrier for Targeted Antiglioma Oncolytic Virotherapy." J Natl Cancer Inst 105, no. 13 (Jul 3 2013): 968-77.

    Alexiades, N. G., B. Auffinger, C. K. Kim, T. Hasan, G. Lee, M. Deheeger, A. L. Tobias, et al. "Mmp14 as a Novel Downstream Target of Vegfr2 in Migratory Glioma-Tropic Neural Stem Cells." [In English]. Stem Cell Research 15, no. 3 (Nov 2015): 598-607.

    Almendros, I., A. Khalyfa, W. Trzepizur, A. Gileles-Hillel, L. Huang, M. Akbarpour, J. Andrade, R. Farre, and D. Gozal. "Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea." Chest  (Aug 25 2016).

    Arina, A., C. Idel, E. M. Hyjek, M. L. Alegre, Y. Wang, V. P. Bindokas, R. R. Weichselbaum, and H. Schreiber. "Tumor-Associated Fibroblasts Predominantly Come from Local and Not Circulating Precursors." Proc Natl Acad Sci U S A 113, no. 27 (Jul 5 2016): 7551-6.

    Arina, A., K. Schreiber, D. C. Binder, T. G. Karrison, R. B. Liu, and H. Schreiber. "Adoptively Transferred Immune T Cells Eradicate Established Tumors Despite Cancer-Induced Immune Suppression." J Immunol 192, no. 3 (Feb 1 2014): 1286-93.

    Bechill, J., R. Zhong, C. Zhang, E. Solomaha, and M. T. Spiotto. "A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates P53." PLoS One 11, no. 4 (2016): e0154125.

    Bernal, G. M., M. J. LaRiviere, N. Mansour, P. Pytel, K. E. Cahill, D. J. Voce, S. Kang, et al. "Convection-Enhanced Delivery and in Vivo Imaging of Polymeric Nanoparticles for the Treatment of Malignant Glioma." Nanomedicine 10, no. 1 (Jan 2014): 149-57.

    Bockhorn, J., R. Dalton, C. Nwachukwu, S. Huang, A. Prat, K. Yee, Y. F. Chang, et al. "Microrna-30c Inhibits Human Breast Tumour Chemotherapy Resistance by Regulating Twf1 and Il-11." Nat Commun 4 (2013): 1393.

    Bockhorn, J., A. Prat, Y. F. Chang, X. Liu, S. Huang, M. Shang, C. Nwachukwu, et al. "Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models." Cancer Res 74, no. 24 (Dec 15 2014): 7406-17.

    Bockhorn, J., K. Yee, Y. F. Chang, A. Prat, D. Huo, C. Nwachukwu, R. Dalton, et al. "Microrna-30c Targets Cytoskeleton Genes Involved in Breast Cancer Cell Invasion." Breast Cancer Res Treat 137, no. 2 (Jan 2013): 373-82.

    Chang, A. L., J. Miska, D. A. Wainwright, M. Dey, C. V. Rivetta, D. Yu, D. Kanojia, et al. "Ccl2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells." Cancer Res 76, no. 19 (Oct 1 2016): 5671-82.

    Cheng, Y., Q. Dai, R. A. Morshed, X. Fan, M. L. Wegscheid, D. A. Wainwright, Y. Han, et al. "Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging." Small 10, no. 24 (Dec 29 2014): 5137-50.

    Chourasia, A. H., K. Tracy, C. Frankenberger, M. L. Boland, M. N. Sharifi, L. E. Drake, J. R. Sachleben, et al. "Mitophagy Defects Arising from Bnip3 Loss Promote Mammary Tumor Progression to Metastasis." EMBO Rep 16, no. 9 (Sep 2015): 1145-63.

    Clark, R., V. Krishnan, M. Schoof, I. Rodriguez, B. Theriault, M. Chekmareva, and C. Rinker-Schaeffer. "Milky Spots Promote Ovarian Cancer Metastatic Colonization of Peritoneal Adipose in Experimental Models." Am J Pathol 183, no. 2 (Aug 2013): 576-91.

    Duan, X., D. Liu, C. Chan, and W. Lin. "Polymeric Micelle-Mediated Delivery of DNA-Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment." Small 11, no. 32 (Aug 26 2015): 3962-72.

    Efimova, E. V., S. Takahashi, N. A. Shamsi, D. Wu, E. Labay, O. A. Ulanovskaya, R. R. Weichselbaum, S. A. Kozmin, and S. J. Kron. "Linking Cancer Metabolism to DNA Repair and Accelerated Senescence." Mol Cancer Res 14, no. 2 (Feb 2016): 173-84.

    Grdina, D. J., J. S. Murley, R. C. Miller, H. J. Mauceri, H. G. Sutton, J. J. Li, G. E. Woloschak, and R. R. Weichselbaum. "A Survivin-Associated Adaptive Response in Radiation Therapy." Cancer Res 73, no. 14 (Jul 15 2013): 4418-28.

    Hamamoto, R., G. Toyokawa, M. Nakakido, K. Ueda, and Y. Nakamura. "Smyd2-Dependent Hsp90 Methylation Promotes Cancer Cell Proliferation by Regulating the Chaperone Complex Formation." Cancer Lett 351, no. 1 (Aug 28 2014): 126-33.

    He, C., X. Duan, N. Guo, C. Chan, C. Poon, R. R. Weichselbaum, and W. Lin. "Core-Shell Nanoscale Coordination Polymers Combine Chemotherapy and Photodynamic Therapy to Potentiate Checkpoint Blockade Cancer Immunotherapy." Nat Commun 7 (2016): 12499.

    He, C., D. Liu, and W. Lin. "Self-Assembled Nanoscale Coordination Polymers Carrying Sirnas and Cisplatin for Effective Treatment of Resistant Ovarian Cancer." Biomaterials 36 (Jan 2015): 124-33.

    He, C., K. Lu, D. Liu, and W. Lin. "Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cisplatin and Pooled Sirnas to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells." J Am Chem Soc 136, no. 14 (Apr 9 2014): 5181-4.

    Heitmann, J., P. Geeleher, Z. Zuo, R. R. Weichselbaum, E. E. Vokes, S. Fetscher, and T. Y. Seiwert. "Poly (Adp-Ribose) Polymerase Inhibitor Efficacy in Head and Neck Cancer." Oral Oncol 50, no. 9 (Sep 2014): 825-31.

    Kanojia, D., I. V. Balyasnikova, R. A. Morshed, R. T. Frank, D. Yu, L. Zhang, D. A. Spencer, et al. "Neural Stem Cells Secreting Anti-Her2 Antibody Improve Survival in a Preclinical Model of Her2 Overexpressing Breast Cancer Brain Metastases." Stem Cells 33, no. 10 (Oct 2015): 2985-94.

    Kanojia, D., R. A. Morshed, L. Zhang, J. M. Miska, J. Qiao, J. W. Kim, P. Pytel, et al. "Betaiii-Tubulin Regulates Breast Cancer Metastases to the Brain." Mol Cancer Ther 14, no. 5 (May 2015): 1152-61.

    Kanteti, R., E. El-Hashani, I. Dhanasingh, M. Tretiakova, A. N. Husain, S. Sharma, J. Sharma, E. E. Vokes, and R. Salgia. "Role of Pax8 in the Regulation of Met and Ron Receptor Tyrosine Kinases in Non-Small Cell Lung Cancer." BMC Cancer 14 (2014): 185.

    Kawada, I., R. Hasina, F. E. Lennon, V. P. Bindokas, P. Usatyuk, Y. H. Tan, S. Krishnaswamy, et al. "Paxillin Mutations Affect Focal Adhesions and Lead to Altered Mitochondrial Dynamics: Relevance to Lung Cancer." Cancer Biol Ther 14, no. 7 (Jul 2013): 679-91.

    Keck, M. K., Z. Zuo, A. Khattri, T. P. Stricker, C. D. Brown, M. Imanguli, D. Rieke, et al. "Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct Hpv and Three Non-Hpv Subtypes." Clin Cancer Res 21, no. 4 (Feb 15 2015): 870-81.

    Keerthivasan, S., K. Aghajani, M. Dose, L. Molinero, M. W. Khan, V. Venkateswaran, C. Weber, et al. "Beta-Catenin Promotes Colitis and Colon Cancer through Imprinting of Proinflammatory Properties in T Cells." Sci Transl Med 6, no. 225 (Feb 26 2014): 225ra28.

    Kenny, H. A., M. Lal-Nag, E. A. White, M. Shen, C. Y. Chiang, A. K. Mitra, Y. Zhang, et al. "Quantitative High Throughput Screening Using a Primary Human Three-Dimensional Organotypic Culture Predicts in Vivo Efficacy." Nat Commun 6 (2015): 6220.

    Khalyfa, A., I. Almendros, A. Gileles-Hillel, M. Akbarpour, W. Trzepizur, B. Mokhlesi, L. Huang, et al. "Circulating Exosomes Potentiate Tumor Malignant Properties in a Mouse Model of Chronic Sleep Fragmentation." Oncotarget  (Jul 13 2016).

    Kim, C. K., A. U. Ahmed, B. Auffinger, I. V. Ulasov, A. L. Tobias, K. S. Moon, and M. S. Lesniak. "N-Acetylcysteine Amide Augments the Therapeutic Effect of Neural Stem Cell-Based Antiglioma Oncolytic Virotherapy." Mol Ther 21, no. 11 (Nov 2013): 2063-73.

    Kregel, S., K. J. Kiriluk, A. M. Rosen, Y. Cai, E. E. Reyes, K. B. Otto, W. Tom, et al. "Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate Cancer." PLoS One 8, no. 1 (2013): e53701.

    Labay, E., H. J. Mauceri, E. V. Efimova, A. C. Flor, H. G. Sutton, S. J. Kron, and R. R. Weichselbaum. "Repurposing Cephalosporin Antibiotics as Pro-Senescent Radiosensitizers." Oncotarget 7, no. 23 (Jun 7 2016): 33919-33.

    Lao, J. P., V. Cloud, C. C. Huang, J. Grubb, D. Thacker, C. Y. Lee, M. E. Dresser, N. Hunter, and D. K. Bishop. "Meiotic Crossover Control by Concerted Action of Rad51-Dmc1 in Homolog Template Bias and Robust Homeostatic Regulation." PLoS Genet 9, no. 12 (2013): e1003978.

    Lee, J., J. Lee, K. S. Farquhar, J. Yun, C. A. Frankenberger, E. Bevilacqua, K. Yeung, et al. "Network of Mutually Repressive Metastasis Regulators Can Promote Cell Heterogeneity and Metastatic Transitions." Proc Natl Acad Sci U S A 111, no. 3 (Jan 21 2014): E364-73.

    Leisegang, M., B. Engels, K. Schreiber, P. Y. Yew, K. Kiyotani, C. Idel, A. Arina, et al. "Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation." Clin Cancer Res 22, no. 11 (Jun 1 2016): 2734-43.

    Lennon, F. E., G. C. Cianci, R. Kanteti, J. J. Riehm, Q. Arif, V. A. Poroyko, E. Lupovitch, et al. "Unique Fractal Evaluation and Therapeutic Implications of Mitochondrial Morphology in Malignant Mesothelioma." Sci Rep 6 (2016): 24578.

    Lennon, F. E., T. Mirzapoiazova, N. Mambetsariev, B. Mambetsariev, R. Salgia, and P. A. Singleton. "Transactivation of the Receptor-Tyrosine Kinase Ephrin Receptor A2 Is Required for the Low Molecular Weight Hyaluronan-Mediated Angiogenesis That Is Implicated in Tumor Progression." J Biol Chem 289, no. 35 (Aug 29 2014): 24043-58.

    Li, G., W. Ci, S. Karmakar, K. Chen, R. Dhar, Z. Fan, Z. Guo, et al. "Spop Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer." Cancer Cell 25, no. 4 (Apr 14 2014): 455-68.

    Liu, D., C. Poon, K. Lu, C. He, and W. Lin. "Self-Assembled Nanoscale Coordination Polymers with Trigger Release Properties for Effective Anticancer Therapy." Nat Commun 5 (2014): 4182.

    Liu, H., J. Yue, H. Huang, X. Gou, S. Y. Chen, Y. Zhao, and X. Wu. "Regulation of Focal Adhesion Dynamics and Cell Motility by the Eb2 and Hax1 Protein Complex." J Biol Chem 290, no. 52 (Dec 25 2015): 30771-82.

    Liu, H., J. Yue, Q. Lei, X. Gou, S. Y. Chen, Y. Y. He, and X. Wu. "Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics." Photochem Photobiol 91, no. 4 (Jul-Aug 2015): 909-16.

    Lu, K., C. He, and W. Lin. "A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers." J Am Chem Soc 137, no. 24 (Jun 24 2015): 7600-3.

    Lu, R., S. Wu, Y. G. Zhang, Y. Xia, Z. Zhou, I. Kato, H. Dong, M. Bissonnette, and J. Sun. "Salmonella Protein Avra Activates the Stat3 Signaling Pathway in Colon Cancer." Neoplasia 18, no. 5 (May 2016): 307-16.

    Ming, M., W. Han, B. Zhao, N. R. Sundaresan, C. X. Deng, M. P. Gupta, and Y. Y. He. "Sirt6 Promotes Cox-2 Expression and Acts as an Oncogene in Skin Cancer." Cancer Res 74, no. 20 (Oct 15 2014): 5925-33.

    Mirzapoiazova, T., N. Mambetsariev, F. E. Lennon, B. Mambetsariev, J. E. Berlind, R. Salgia, and P. A. Singleton. "Habp2 Is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression." Front Oncol 5 (2015): 164.

    Morshed, R. A., M. Gutova, J. Juliano, M. E. Barish, A. Hawkins-Daarud, D. Oganesyan, K. Vazgen, et al. "Analysis of Glioblastoma Tumor Coverage by Oncolytic Virus-Loaded Neural Stem Cells Using Mri-Based Tracking and Histological Reconstruction." Cancer Gene Ther 22, no. 1 (Jan 2015): 55-61.

    Nakakido, M., Z. Deng, T. Suzuki, N. Dohmae, Y. Nakamura, and R. Hamamoto. "Dysregulation of Akt Pathway by Smyd2-Mediated Lysine Methylation on Pten." Neoplasia 17, no. 4 (Apr 2015): 367-73.

    Nakakido, M., K. Tamura, S. Chung, K. Ueda, R. Fujii, K. Kiyotani, and Y. Nakamura. "Phosphatidylinositol Glycan Anchor Biosynthesis, Class X Containing Complex Promotes Cancer Cell Proliferation through Suppression of Ehd2 and Zic1, Putative Tumor Suppressors." Int J Oncol 49, no. 3 (Sep 2016): 868-76.

    Nakamura, T., T. Katagiri, S. Sato, T. Kushibiki, K. Hontani, T. Tsuchikawa, S. Hirano, and Y. Nakamura. "Overexpression of C16orf74 Is Involved in Aggressive Pancreatic Cancers." Oncotarget  (Jul 28 2016).

    Pekow, J., K. Meckel, U. Dougherty, F. Butun, R. Mustafi, J. Lim, C. Crofton, et al. "Tumor Suppressors Mir-143 and Mir-145 and Predicted Target Proteins Api5, Erk5, K-Ras, and Irs-1 Are Differentially Expressed in Proximal and Distal Colon." Am J Physiol Gastrointest Liver Physiol 308, no. 3 (Feb 1 2015): G179-87.

    Poon, C., C. He, D. Liu, K. Lu, and W. Lin. "Self-Assembled Nanoscale Coordination Polymers Carrying Oxaliplatin and Gemcitabine for Synergistic Combination Therapy of Pancreatic Cancer." J Control Release 201 (Mar 10 2015): 90-9.

    Qiang, L., B. Zhao, M. Ming, N. Wang, T. C. He, S. Hwang, A. Thorburn, and Y. Y. He. "Regulation of Cell Proliferation and Migration by P62 through Stabilization of Twist1." Proc Natl Acad Sci U S A 111, no. 25 (Jun 24 2014): 9241-6.

    Ranoa, D. R., A. D. Parekh, S. P. Pitroda, X. Huang, T. Darga, A. C. Wong, L. Huang, et al. "Cancer Therapies Activate Rig-I-Like Receptor Pathway through Endogenous Non-Coding Rnas." Oncotarget 7, no. 18 (May 3 2016): 26496-515.

    Rolle, C. E., R. Kanteti, M. Surati, S. Nandi, I. Dhanasingh, S. Yala, M. Tretiakova, et al. "Combined Met Inhibition and Topoisomerase I Inhibition Block Cell Growth of Small Cell Lung Cancer." Mol Cancer Ther 13, no. 3 (Mar 2014): 576-84.

    Sharifi, M. N., E. E. Mowers, L. E. Drake, and K. F. Macleod. "Measuring Autophagy in Stressed Cells." Methods Mol Biol 1292 (2015): 129-50.

    Skor, M. N., E. L. Wonder, M. Kocherginsky, A. Goyal, B. A. Hall, Y. Cai, and S. D. Conzen. "Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer." Clin Cancer Res 19, no. 22 (Nov 15 2013): 6163-72.

    Sone, K., L. Piao, M. Nakakido, K. Ueda, T. Jenuwein, Y. Nakamura, and R. Hamamoto. "Critical Role of Lysine 134 Methylation on Histone H2ax for Gamma-H2ax Production and DNA Repair." Nat Commun 5 (2014): 5691.

    Spranger, S., R. Bao, and T. F. Gajewski. "Melanoma-Intrinsic Beta-Catenin Signalling Prevents Anti-Tumour Immunity." Nature 523, no. 7559 (Jul 9 2015): 231-5.

    Stoddart, A., Z. Qian, A. A. Fernald, R. J. Bergerson, J. Wang, T. Karrison, J. Anastasi, et al. "Retroviral Insertional Mutagenesis Identifies the Del(5q) Genes, Cxxc5, Tifab and Etf1, as Well as the Wnt Pathway, as Potential Targets in Del(5q) Myeloid Neoplasms." Haematologica 101, no. 6 (Jun 2016): e232-6.

    Sundaravel, S., R. Duggan, T. Bhagat, D. L. Ebenezer, H. Liu, Y. Yu, M. Bartenstein, et al. "Reduced Dock4 Expression Leads to Erythroid Dysplasia in Myelodysplastic Syndromes." Proc Natl Acad Sci U S A 112, no. 46 (Nov 17 2015): E6359-68.

    Tarhan, Y. E., T. Kato, M. Jang, Y. Haga, K. Ueda, Y. Nakamura, and J. H. Park. "Morphological Changes, Cadherin Switching, and Growth Suppression in Pancreatic Cancer by Galnt6 Knockdown." Neoplasia 18, no. 5 (May 2016): 265-72.

    Ulasov, I., B. Thaci, P. Sarvaiya, R. Yi, D. Guo, B. Auffinger, P. Pytel, et al. "Inhibition of Mmp14 Potentiates the Therapeutic Effect of Temozolomide and Radiation in Gliomas." Cancer Med 2, no. 4 (Aug 2013): 457-67.

    Uppal, A., S. C. Wightman, S. Mallon, G. Oshima, S. P. Pitroda, Q. Zhang, X. Huang, et al. "14q32-Encoded Micrornas Mediate an Oligometastatic Phenotype." Oncotarget 6, no. 6 (Feb 28 2015): 3540-52.

    Veselits, M., A. Tanaka, S. Lipkowitz, S. O'Neill, R. Sciammas, A. Finnegan, J. Zhang, and M. R. Clark. "Recruitment of Cbl-B to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes." PLoS One 9, no. 3 (2014): e89792.

    Wang, X., Z. Lu, A. Gomez, G. C. Hon, Y. Yue, D. Han, Y. Fu, et al. "N6-Methyladenosine-Dependent Regulation of Messenger Rna Stability." Nature 505, no. 7481 (Jan 2 2014): 117-20.

    Yue, J., M. Xie, X. Gou, P. Lee, M. D. Schneider, and X. Wu. "Microtubules Regulate Focal Adhesion Dynamics through Map4k4." Dev Cell 31, no. 5 (Dec 8 2014): 572-85.

    Zhang, Y., H. A. Kenny, E. P. Swindell, A. K. Mitra, P. L. Hankins, R. W. Ahn, K. Gwin, et al. "Urokinase Plasminogen Activator System-Targeted Delivery of Nanobins as a Novel Ovarian Cancer Therapy." Mol Cancer Ther 12, no. 12 (Dec 2013): 2628-39.

    Zhao, B., P. Shah, A. V. Budanov, L. Qiang, M. Ming, A. Aplin, D. M. Sims, and Y. Y. He. "Sestrin2 Protein Positively Regulates Akt Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells." J Biol Chem 289, no. 52 (Dec 26 2014): 35806-14.

    Zhao, Y., Y. Lin, H. Zhang, A. Manas, W. Tang, Y. Zhang, D. Wu, A. Lin, and J. Xiang. "Ubl4a Is Required for Insulin-Induced Akt Plasma Membrane Translocation through Promotion of Arp2/3-Dependent Actin Branching." Proc Natl Acad Sci U S A 112, no. 31 (Aug 4 2015): 9644-9.

    Zhong, R., R. Bao, P. W. Faber, V. P. Bindokas, J. Bechill, M. W. Lingen, and M. T. Spiotto. "Notch1 Activation or Loss Promotes Hpv-Induced Oral Tumorigenesis." Cancer Res 75, no. 18 (Sep 15 2015): 3958-69.